An expedient and new synthesis of pyrrolo[1,2-b]pyridazine derivatives

• Rajeshwar Reddy Sagyam,
• Ravinder Buchikonda,
• Jaya Prakash Pitta,
• Himabindu Vurimidi,
• Pratap Reddy Padi and
• Mahesh Reddy Ghanta

Beilstein J. Org. Chem. 2009, 5, No. 66, doi:10.3762/bjoc.5.66

• -methyl-3-oxo-pentanoic acid phenylamide with tertiary butyl carbazate and subsequent condensation of the resulting carbamate derivative with a chalcone provided a facile new approach to pyrrolo[1,2-b]pyridazine derivatives. Keywords: 1,4-diketone; migration and cyclization; pyrrolo[1,2-b]pyridazine

• ; tertiary butyl carbamate; tertiary butyl carbazate; α,β-unsaturated ketone; Introduction Pyrrolopyridazine derivatives have various biological applications [1][2][3][4][5][6][7][8], and their fluorescent properties have been investigated for potential use in sensors, lasers, and semiconductor devices [9

• ]pyridazines through a hitherto unprecedented approach from a BOC-protected 1-aminopyrrole derivative and α,β-unsaturated ketones. Results and Discussion 2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-pentanoic acid phenylamide 1 was reacted with tertiary butyl carbazate 2 in toluene and cyclohexane